作者
Matt Lechner, Yoko Takahashi, Mario Turri-Zanoni, Jacklyn Liu, Nicholas Counsell, Mario Hermsen, Raman Preet Kaur, Tianna Zhao, Murugappan Ramanathan Jr, Volker H Schartinger, Oscar Emanuel, Sam Helman, Jordan Varghese, Jozsef Dudas, Herbert Riechelmann, Susanne Sprung, Johannes Haybaeck, David Howard, Nils Wolfgang Engel, Sarah Stewart, Laura Brooks, Jessica C Pickles, Thomas S Jacques, Tim R Fenton, Luke Williams, Francis M Vaz, Paul O'Flynn, Paul Stimpson, Simon Wang, S Alam Hannan, Samit Unadkat, Jonathan Hughes, Raghav Dwivedi, Cillian T Forde, Premjit Randhawa, Simon Gane, Jonathan Joseph, Peter J Andrews, Gary Royle, Alessandro Franchi, Roberta Maragliano, Simonetta Battocchio, Helen Bewicke-Copley, Christodoulos Pipinikas, Amy Webster, Chrissie Thirlwell, Debbie Ho, Andrew Teschendorff, Tianyu Zhu, Christopher D Steele, Nischalan Pillay, Bart Vanhaesebroeck, Ahmed Mohyeldin, Juan Fernandez-Miranda, Ki Wan Park, Quynh-Thu Le, Robert B West, Rami Saade, R Peter Manes, Sacit Bulent Omay, Eugenia M Vining, Benjamin L Judson, Wendell G Yarbrough, Maddalena Sansovini, Nicolini Silvia, Ilaria Grassi, Alberto Bongiovanni, David Capper, Ulrich Schüller, Selvam Thavaraj, Ann Sandison, Pavol Surda, Claire Hopkins, Marco Ferrari, Davide Mattavelli, Vittorio Rampinelli, Fabio Facchetti, Piero Nicolai, Paolo Bossi, Oswaldo A Henriquez, Kelly Magliocca, C Arturo Solares, Sarah K Wise, Jose L Llorente, Zara M Patel, Jayakar V Nayak, Peter H Hwang, Peter D Lacy, Robbie Woods, James P O'Neill, Amrita Jay, Dawn Carnell, Martin D Forster, Masaru Ishii, Nyall R London Jr, Diana M Bell, Gary L Gallia, Paolo Castelnuovo, Stefano Severi, Valerie J Lund, Ehab Y Hanna
发表日期
2022/2/1
期刊
European Journal of Cancer
卷号
162
页码范围
221-236
出版商
Pergamon
简介
Introduction
Olfactory neuroblastoma (ONB) is a rare cancer of the sinonasal region. We provide a comprehensive analysis of this malignancy with molecular and clinical trial data on a subset of our cohort to report on the potential efficacy of somatostatin receptor 2 (SSTR2)-targeting imaging and therapy.
Methods
We conducted a retrospective analysis of 404 primary, locally recurrent, and metastatic olfactory neuroblastoma (ONB) patients from 12 institutions in the United States of America, United Kingdom and Europe. Clinicopathological characteristics and treatment approach were evaluated. SSTR2 expression, SSTR2-targeted imaging and the efficacy of peptide receptor radionuclide therapy [PRRT](177Lu-DOTATATE) were reported in a subset of our cohort (LUTHREE trial; NCT03454763).
Results
Dural infiltration at presentation was a significant predictor of overall survival (OS) and disease-free survival (DFS …
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M Lechner, Y Takahashi, M Turri-Zanoni, J Liu… - European Journal of Cancer, 2022