作者
Moe H Kyaw, Ruth Lynfield, William Schaffner, Allen S Craig, James Hadler, Arthur Reingold, Ann R Thomas, Lee H Harrison, Nancy M Bennett, Monica M Farley, Richard R Facklam, James H Jorgensen, John Besser, Elizabeth R Zell, Anne Schuchat, Cynthia G Whitney
发表日期
2006/4/6
期刊
New England Journal of Medicine
卷号
354
期号
14
页码范围
1455-1463
出版商
Massachusetts Medical Society
简介
Background
Five of seven serotypes in the pneumococcal conjugate vaccine, introduced for infants in the United States in 2000, are responsible for most penicillin-resistant infections. We examined the effect of this vaccine on invasive disease caused by resistant strains.
Methods
We used laboratory-based data from Active Bacterial Core surveillance to measure disease caused by antibiotic-nonsusceptible pneumococci from 1996 through 2004. Cases of invasive disease, defined as disease caused by pneumococci isolated from a normally sterile site, were identified in eight surveillance areas. Isolates underwent serotyping and susceptibility testing.
Results
Rates of invasive disease caused by penicillin-nonsusceptible strains and strains not susceptible to multiple antibiotics peaked in 1999 and decreased by 2004, from 6.3 to 2.7 cases per 100,000 (a decline of 57 percent; 95 percent confidence interval, 55 to …
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MH Kyaw, R Lynfield, W Schaffner, AS Craig, J Hadler… - New England Journal of Medicine, 2006