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We herein describe a simple setup for the automated simultaneous synthesis of l-[methyl-¹¹C]methionine and N-[methyl-¹¹C]choline by solid-supported methylation . The setup is extremely simple and easy to adapt to other automated systems and due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [¹¹C]methylation step. Furthermore, it can be used for multiple simultaneous synthesis.