作者
Josep M Antó, Mariona Pinart, Mübeccel Akdis, Charles Auffray, Claus Bachert, Xavier Basagaña, Kai-Håkon Carlsen, Stefano Guerra, Leena Von Hertzen, Sabina Illi, Francine Kauffmann, Thomas Keil, James P Kiley, Gerard H Koppelman, Christian Lupinek, Fernando D Martinez, Martijn C Nawijn, Dirkje S Postma, Valérie Siroux, Henriette A Smit, Peter J Sterk, Jordi Sunyer, Rudolf Valenta, Sergio Valverde, Cezmi A Akdis, Isabella Annesi-Maesano, Ferran Ballester, Marta Benet, Anne Cambon-Thomsen, Leda Chatzi, Jonathan Coquet, Pascal Demoly, Weiniu Gan, Judith Garcia-Aymerich, Elena Gimeno-Santos, Chantal Guihenneuc-Jouyaux, Tari Haahtela, Joachim Heinrich, Marie Herr, Cynthia Hohmann, Bénédicte Jacquemin, Jocelyne Just, Marjan Kerkhof, Manolis Kogevinas, Marek L Kowalski, Bart N Lambrecht, Susanne Lau, Karin C Lødrup Carlsen, Dieter Maier, Isabelle Momas, Patricia Noel, Sam Oddie, Susanna Palkonen, Isabelle Pin, Daniela Porta, Antonello Punturieri, Fanny Rancière, Robert A Smith, Barbara Stanic, Renato T Stein, Willem Van De Veen, Antoon JM Van Oosterhout, Raphaelle Varraso, Magnus Wickman, Cisca Wijmenga, John Wright, Gorkem Yaman, Torsten Zuberbier, Jean Bousquet, WHO Collaborating Centre on Asthma
发表日期
2012/4/1
来源
Journal of Allergy and Clinical Immunology
卷号
129
期号
4
页码范围
943-954. e4
出版商
Mosby
简介
Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the …
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JM Antó, M Pinart, M Akdis, C Auffray, C Bachert… - Journal of Allergy and Clinical Immunology, 2012