作者
Willem van de Veen, Barbara Stanic, Görkem Yaman, Marcin Wawrzyniak, Stefan Söllner, Deniz G Akdis, Beate Rückert, Cezmi A Akdis, Mübeccel Akdis
发表日期
2013/4/1
期刊
Journal of Allergy and Clinical Immunology
卷号
131
期号
4
页码范围
1204-1212
出版商
Mosby
简介
BACKGROUND
IL-10–producing regulatory B cells suppress immune responses, and lack of these cells leads to exacerbated symptoms in mouse models of chronic inflammation, transplantation, and chronic infection. IgG4 is a blocking antibody isotype with anti-inflammatory potential that is induced in human high-dose antigen tolerance models.
OBJECTIVE
We sought to characterize human inducible IL-10–secreting B regulatory 1 (BR1) cells and to investigate their immunoregulatory capacity through suppression of cellular immune responses and production of anti-inflammatory immunoglobulins.
METHODS
Highly purified IL-10–secreting B cells were phenotypically and functionally characterized by means of whole-genome expression analysis, flow cytometry, suppression assay, and antibody production. B cells specific for the major bee venom allergen phospholipase A2 (PLA) were isolated from beekeepers …
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W van de Veen, B Stanic, G Yaman, M Wawrzyniak… - Journal of Allergy and Clinical Immunology, 2013