作者
Marina Chiara Garassino, Olga Martelli, Massimo Broggini, Gabriella Farina, Silvio Veronese, Eliana Rulli, Filippo Bianchi, Anna Bettini, Flavia Longo, Luca Moscetti, Maurizio Tomirotti, Mirko Marabese, Monica Ganzinelli, Calogero Lauricella, Roberto Labianca, Irene Floriani, Giuseppe Giaccone, Valter Torri, Alberto Scanni, Silvia Marsoni
发表日期
2013/9/1
期刊
The lancet oncology
卷号
14
期号
10
页码范围
981-988
出版商
Elsevier
简介
Background
Erlotinib is registered for treatment of all patients with advanced non-small-cell lung cancer (NSCLC). However, its efficacy for treatment of patients whose tumours are EGFR wild-type—which includes most patients—is still contentious. We assessed the efficacy of erlotinib compared with a standard second-line chemotherapy in such patients.
Methods
We did this randomised controlled trial in 52 Italian hospitals. We enrolled patients who had metastatic NSCLC, had had platinum-based chemotherapy, and had wild-type EGFR as assessed by direct sequencing. Patients were randomly assigned centrally (1:1) to receive either erlotinib orally 150 mg/day or docetaxel intravenously 75 mg/m2 every 21 days or 35 mg/m2 on days 1, 8, and 15, every 28 days. Randomisation was stratified by centre, stage, type of first-line chemotherapy, and performance status. Patients and investigators who gave treatments or …
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MC Garassino, O Martelli, M Broggini, G Farina… - The lancet oncology, 2013