作者
Amir Pejman Hashemi Taheri, Amir Reza Radmard, Soheil Kooraki, Maryam Behfar, Neda Pak, Amir Ali Hamidieh, Ardeshir Ghavamzadeh
发表日期
2015/9
期刊
Pediatric Blood & Cancer
卷号
62
期号
9
页码范围
1645-1649
简介
Introduction
Hematopoietic stem cell transplantation (HSCT) is the only known curative treatment of malignant infantile osteopetrosis (MIOP). In this study, short‐term serial bone surveys were used to assess radiologic evolution of skeletal changes after HSCT in MIOP.
Materials and Methods
Baseline whole‐body bone survey was performed in all patients. HSCT was successful in 14 patients (11 with full chimerism, three with mixed chimerism) in whom follow‐up bone surveys were carried out at 6 and 12 months after HSCT.
Results
Normal corticomedullary differentiation was evident in five (P = 0.06) and 12 (P < 0.005) patients at 6 and 12 months, respectively. Abnormal endobone appearance in long bones, present in 11 participants at baseline exam, disappeared in eight (P = 0.008) and all (P = 0.001) patients at 6 and 12 months, respectively. In 6‐month follow‐up, rachitic changes significantly …
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AP Hashemi Taheri, AR Radmard, S Kooraki, M Behfar… - Pediatric Blood & Cancer, 2015