作者
Jesse D Cochran, Yoshimitsu Yura, Mark C Thel, Heather Doviak, Ariel H Polizio, Yuka Arai, Yohei Arai, Keita Horitani, Eunbee Park, Nicholas W Chavkin, Anupreet Kour, Soichi Sano, Nitin Mahajan, Megan Evans, Mahalia Huba, Nadia Martinez Naya, Hanna Sun, Young Ho Ban, Karen K Hirschi, Stefano Toldo, Antonio Abbate, Todd E Druley, Frederick L Ruberg, Mathew S Maurer, Justin A Ezekowitz, Jason RB Dyck, Kenneth Walsh
发表日期
2023/10/10
期刊
Circulation
卷号
148
期号
15
页码范围
1165-1178
出版商
Lippincott Williams & Wilkins
简介
BACKGROUND
Clonal hematopoiesis (CH), which results from an array of nonmalignant driver gene mutations, can lead to altered immune cell function and chronic disease, and has been associated with worse outcomes in patients with heart failure (HF) with reduced ejection fraction. However, the role of CH in the prognosis of HF with preserved ejection fraction (HFpEF) has been understudied. This study aimed to characterize CH in patients with HFpEF and elucidate its causal role in a murine model.
METHODS
Using a panel of 20 candidate CH driver genes and a variant allele fraction cutoff of 0.5%, ultradeep error-corrected sequencing identified CH in a cohort of 81 patients with HFpEF (mean age, 71±6 years; ejection fraction, 63±5%) and 36 controls without a diagnosis of HFpEF (mean age, 74±7 years; ejection fraction, 61.5±8%). CH was also evaluated in a replication cohort of 59 individuals with HFpEF …
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JD Cochran, Y Yura, MC Thel, H Doviak, AH Polizio… - Circulation, 2023