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Demonstrated the importance of central noradrenaline in maintaining attention. 74 adult men were challenged with placebo, idazoxan, clonidine (which acts presynaptically to decrease noradrenergic cell firing and noradrenaline release), or clonidine plus idazoxan under quiet or noisy conditions. Clonidine-induced lapses of attention on an reaction time (RT) task were reversed by idazoxan and by noise.(PsycINFO Database Record (c) 2016 APA, all rights reserved)