作者
Lixiang Wang, Takaya Ishihara, Yuta Ibayashi, Keita Tatsushima, Daiki Setoyama, Yuki Hanada, Yukina Takeichi, Shohei Sakamoto, Sadaki Yokota, Katsuyoshi Mihara, Dongchon Kang, Naotada Ishihara, Ryoichi Takayanagi, Masatoshi Nomura
发表日期
2015/10
期刊
Diabetologia
卷号
58
页码范围
2371-2380
出版商
Springer Berlin Heidelberg
简介
Aim/hypothesis
Mitochondria and the endoplasmic reticulum (ER) physically interact by close structural juxtaposition, via the mitochondria-associated ER membrane. Inter-organelle communication between the ER and mitochondria has been shown to regulate energy metabolism and to be central to the modulation of various key processes such as ER stress. We aimed to clarify the role of mitochondrial fission in this communication.
Methods
We generated mice lacking the mitochondrial fission protein dynamin-related protein 1 (DRP1) in the liver (Drp1LiKO mice).
Results
Drp1LiKO mice showed decreased fat mass and were protected from high-fat diet (HFD)-induced obesity. Analysis of liver gene expression profiles demonstrated marked elevation of ER stress markers. In addition, we observed …
学术搜索中的文章
L Wang, T Ishihara, Y Ibayashi, K Tatsushima… - Diabetologia, 2015