查看文章

Purpose: To review the outcomes of patients with low-grade glioma diagnosed by modern imaging and treated at a center where postponing radiotherapy was common practice.

Methods: We reviewed the records of patients (age

2 18 years) with pathologically confirmed supratentorial low-grade fibrillary astrocytoma, oligodendroglioma, and mixed glioma treated at a regional cancer center in Canada between 1979 and 1995.

Results: Median survival for the entire group (N=

167; mean age 40.6 years) was 10.5 years with 5-and 10-year survival rates of 72% and 50%, respectively. Median progression-free survival was 4.9 years with 5-and 10-year progression-free rates of 50% and 12%, respectively. Overall and progression-free survivals were longer for patients with an oligodendroglioma or mixed glioma than with astrocytoma (median 13 v 7.5 years, P=. 003; progression-free 5.6 v 4.4 years, P=. 054). Age at diagnosis< 40 years, seizures at presenta-