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Dengue fever is the most important mosquito-borne viral disease of humans with more than 50 million cases estimated annually in more than 100 countries^,. Disturbingly, the geographic range of dengue is currently expanding and the severity of outbreaks is increasing^,,. Control options for dengue are very limited and currently focus on reducing population abundance of the major mosquito vector, Aedes aegypti^,. These strategies are failing to reduce dengue incidence in tropical communities and there is an urgent need for effective alternatives. It has been proposed that endosymbiotic bacterial Wolbachia infections of insects might be used in novel strategies for dengue control^,,. For example, the wMelPop-CLA Wolbachia strain reduces the lifespan of adult A. aegypti mosquitoes in stably transinfected lines. This life-shortening phenotype was predicted to reduce the potential for dengue transmission. The recent …