作者
Cristian Loretelli, Francesca Rocchio, Francesca D'Addio, Moufida Ben Nasr, Eduardo Castillo-Leon, Sergio Dellepiane, Andrea Vergani, Ahmed Abdelsalam, Emma Assi, Anna Maestroni, Vera Usuelli, Roberto Bassi, Ida Pastore, Jun Yang, Basset El Essawy, Khalid M Elased, Gian Paolo Fadini, Elio Ippolito, Andy Joe Seelam, Marcus Pezzolesi, Domenico Corradi, Gian Vincenzo Zuccotti, Maurizio Gallieni, Marcello Allegretti, Monika Anna Niewczas, Paolo Fiorina
发表日期
2021/8/1
期刊
Metabolism
卷号
121
页码范围
154804
出版商
WB Saunders
简介
Aims/hypothesis
Inflammation has a major role in diabetic kidney disease. We thus investigated the role of the IL-8-CXCR1/2 axis in favoring kidney damage in diabetes.
Methods
Urinary IL-8 levels were measured in 1247 patients of the Joslin Kidney Study in type 2 diabetes (T2D). The expression of IL-8 and of its membrane receptors CXCR1/CXCR2 was quantified in kidney tissues in patients with T2D and in controls. The effect of CXCR1/2 blockade on diabetic kidney disease was evaluated in db/db mice.
Results
IL-8 urinary levels were increased in patients with T2D and diabetic kidney disease, with the highest urinary IL-8 levels found in the patients with the largest decline in glomerular filtration rate, with an increased albumin/creatine ratio and the worst renal outcome. Moreover, glomerular IL-8 renal expression was increased in patients with T2D, as compared to controls. High glucose elicits abundant IL-8 …
学术搜索中的文章
C Loretelli, F Rocchio, F D'Addio, MB Nasr… - Metabolism, 2021