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Objective

Oocytes appear to be protected against oxidative stress (OS) by oxygen scavengers that are present in vivo. However, when oocytes are removed from their natural environments for assisted reproduction techniques, this natural defense mechanism is lost. Earlier we demonstrated the damaging effect of oxidative stress induced by exogenous exposure to hydrogen peroxide on metaphase II oocyte microtubule and chromosomal alignment. Therefore, protecting oocytes from oxidative stress in vitro is important. The objective of our study was to examine the protective effect of antioxidant supplementation with vitamin C in reducing OS-induced cytoskeleton damages.

Design