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Application of “bioactive materials”, as a modified version of biomaterials, can optimize the response of the biological system due to their surface reactivity and formation of strong interactions with the adjacent tissue upon implantation. However, choosing an appropriate bioactive material that suits to the application and provides the desired mechanical, physical, chemical and biological functionality, as well as understanding the aspects of biological reaction to the biomaterial, in particular immune response, it plays a key role in successful integration of the implant. In this review, we will discuss different bioactive materials including bioactive ceramics, polymers and composites and their applications in drug delivery and scaffold preparation in order to provide an adequate introduction to the recent studies. Considering the necessity of regulation of implant fate for higher biocompatibility, the comprehensive …