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AGE-related changes of A, and A 2a adenosine receptor binding characteristics were investigated in three regions of the rat brain using the A] selective antagonist [3 H] DPCPX, and the A 2a selective agonist [3 H] CGS 21680. The density of A] binding sites in aged rats (24 months) was decreased by 33% in the hippocampus and by 60% in the cortex and was unchanged in the striatum when compared with young adult rats (6 weeks), with no change in K D-There were also age-related changes in the density of A 2a binding sites: in the cortex, there was a 94% increase in the number of [3 H] CGS 21680 binding sites in aged rats compared with young rats, and a similar tendency was observed in the hippocampus (32% increase in A 2a binding sites in aged rats), with no change in K D; in the striatum there was a tendency for a decrease (22%) in the number of [3 H] CGS 21680 binding sites in aged rats, and a …