作者
Joanna Seiffert, Alison Buckley, Bey Leo, Nicholas G Martin, Jie Zhu, Ranran Dai, Farhana Hussain, Chang Guo, James Warren, Alan Hodgson, Jicheng Gong, Mary P Ryan, Junfeng Zhang, Alexandra Porter, Terry D Tetley, Andrew Gow, Rachel Smith, Kian Fan Chung
发表日期
2016/12
期刊
Respiratory research
卷号
17
页码范围
1-15
出版商
BioMed Central
简介
Background
The increasing use of silver nanoparticles (AgNPs) in consumer products is concerning. We examined the potential toxic effects when inhaled in Brown-Norway (BN) rats with a pre-inflammatory state compared to Sprague–Dawley (SD) rats.
Methods
We determined the effect of AgNPs generated from a spark generator (mass concentration: 600–800 μg/mm3; mean diameter: 13–16 nm; total lung doses: 8 [Low] and 26–28 [High] μg) inhaled by the nasal route in both rat strains. Rats were sacrificed at day 1 and day 7 after exposure and measurement of lung function.
Results
In both strains, there was an increase in neutrophils in bronchoalveolar lavage (BAL) fluid at 24 h at the high dose, with concomitant eosinophilia in BN rats. While BAL inflammatory cells were mostly normalised by Day 7, lung …
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J Seiffert, A Buckley, B Leo, NG Martin, J Zhu, R Dai… - Respiratory research, 2016