作者
Martin Blomberg Jensen, Poul J Bjerrum, Torben E Jessen, John E Nielsen, Ulla N Joensen, Inge A Olesen, Jørgen H Petersen, Anders Juul, Steen Dissing, Niels Jørgensen
发表日期
2011/6/1
期刊
Human reproduction
卷号
26
期号
6
页码范围
1307-1317
出版商
Oxford University Press
简介
BACKGROUND
The vitamin D receptor (VDR) is expressed in human spermatozoa, and VDR-knockout mice and vitamin D (VD) deficiency in rodents results in impaired fertility, low sperm counts and a low number of motile spermatozoa. We investigated the role of activated VD (1,25(OH)2D3) in human spermatozoa and whether VD serum levels are associated with semen quality.
METHODS
Cross-sectional association study of semen quality and VD serum level in 300 men from the general population, and in vitro studies on spermatozoa from 40 men to investigate the effects of VD on intracellular calcium, sperm motility and acrosome reaction. All men delivered samples for routine semen analysis and blood for measurements of follicle stimulating hormone, Inhibin B, 25-hydroxy-VD, albumin, alkaline phosphatase, calcium and parathyroid hormone (PTH …
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M Blomberg Jensen, PJ Bjerrum, TE Jessen… - Human reproduction, 2011