作者
Chang W Song, Yoon-Jin Lee, Robert J Griffin, Inhwan Park, Nathan A Koonce, Susanta Hui, Mi-Sook Kim, Kathryn E Dusenbery, Paul W Sperduto, L Chinsoo Cho
发表日期
2015/9/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
93
期号
1
页码范围
166-172
出版商
Elsevier
简介
Purpose
The purpose of this study was to reveal the biological mechanisms underlying stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS).
Methods and Materials
FSaII fibrosarcomas grown subcutaneously in the hind limbs of C3H mice were irradiated with 10 to 30 Gy of X rays in a single fraction, and the clonogenic cell survival was determined with in vivo–in vitro excision assay immediately or 2 to 5 days after irradiation. The effects of radiation on the intratumor microenvironment were studied using immunohistochemical methods.
Results
After cells were irradiated with 15 or 20 Gy, cell survival in FSaII tumors declined for 2 to 3 days and began to recover thereafter in some but not all tumors. After irradiation with 30 Gy, cell survival declined continuously for 5 days. Cell survival in some tumors 5 days after 20 to 30 Gy irradiation was 2 to 3 logs less than that immediately after …
学术搜索中的文章
CW Song, YJ Lee, RJ Griffin, I Park, NA Koonce, S Hui… - International Journal of Radiation Oncology* Biology …, 2015