作者
Harindra C Wijeysundera, Ram Vijayaraghavan, Brahmajee K Nallamothu, JoAnne M Foody, Harlan M Krumholz, Christopher O Phillips, Amir Kashani, John J You, Jack V Tu, Dennis T Ko
发表日期
2007/1/30
期刊
Journal of the American College of Cardiology
卷号
49
期号
4
页码范围
422-430
出版商
American College of Cardiology Foundation
简介
Objectives
We sought to best estimate the benefits and risks associated with rescue percutaneous coronary intervention (PCI) and repeat fibrinolytic therapy as compared with conservative management in patients with failed fibrinolytic therapy for ST-segment myocardial infarction (STEMI).
Background
Fibrinolytic therapy is the most common treatment for STEMI; however, the best therapy in patients who fail to achieve reperfusion after fibrinolytic therapy remains uncertain.
Methods
We performed a meta-analysis of randomized trials using a fixed-effects model. We included 8 trials enrolling 1,177 patients with follow-up duration ranging from hospital discharge to 6 months.
Results
Rescue PCI was associated with no significant reduction in all-cause mortality (relative risk [RR] 0.69; 95% confidence interval [CI] 0.46 to 1.05), but was associated with significant risk reductions in heart failure (RR 0.73; 95% CI 0.54 to 1.00 …
引用总数
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HC Wijeysundera, R Vijayaraghavan, BK Nallamothu… - Journal of the American College of Cardiology, 2007
