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Left ventricular (LV) remodeling after myocardial infarction (MI) results from hypertrophy of myocytes and activation of fibroblasts induced, in part, by ligand stimulation of the ANG II type 1 receptor (AT₁R). The purpose of the present study was to explore the specific role for activation of the AT_1aR subtype in post-MI remodeling and whether gender differences exist in the patterns of remodeling in wild-type and AT_1aR knockout (KO) mice. AT_1aR-KO mice and wild-type littermates underwent coronary ligation to induce MI or sham procedures; echocardiography and hemodynamic evaluation were performed 6 wk later, and LV tissue was harvested for infarct size determination, morphometric measurements, and gene expression analysis. Survival and infarct size were similar among all male and female wild-type and AT_1aR-KO mice. Hemodynamic indexes were also similar except for lower systolic blood pressure in …