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Growing demand for efficient wastewater treatment systems is spurring on the development of new technologies. Biofilm‐based reactors can be used for the treatment of a variety of wastewaters and these reactors are resistant to toxic environments. Bioreactors, such as sequencing batch biofilm and moving bed biofilm are advanced techniques to treat various types of wastewaters with diverse operating conditions. Ammonium oxidizing bacteria, nitrite oxidizing bacteria and Anammox (anaerobic ammonium oxidation) bacteria are reported to be responsible for nutrient removal. In recent decades, the performance of these systems has been studied widely and compared for a number of wastewater treatment applications. In general, they are particularly suitable for high‐rate nitrification and nitrogen removal. The efficiency of these reactors has been confirmed in the laboratory and large‐scale plants. Their efficiency …