作者
Prasad R Dandawate, Alok Vyas, Aamir Ahmad, Sanjeev Banerjee, Jyoti Deshpande, K Venkateswara Swamy, Abeda Jamadar, Anne Catherine Dumhe-Klaire, Subhash Padhye, Fazlul H Sarkar
发表日期
2012/7
期刊
Pharmaceutical research
卷号
29
页码范围
1775-1786
出版商
Springer US
简介
Purpose
Several formulations have been proposed to improve the systemic delivery of novel cancer therapeutic compounds, including cyclodextrin derivatives. We aimed to synthesize and characterize of CDF-β-cyclodextrin inclusion complex (1:2) (CDFCD).
Methods
The compound was characterized by Fourier transform infrared, differential scanning calorimetry, powder X-ray diffraction studies, H1 & C13 NMR studies and scanning electron microscopic analysis. Its activity was tested against multiple cancer cell lines, and in vivo bioavailability was checked.
Results
CDF-β-cyclodextrin was found to lower IC50 value by half when tested against multiple cancer cell lines. It preferentially accumulated in the pancreas, where levels of CDF-β-cyclodextrin in mice were 10 times higher than in serum, following intravenous …
学术搜索中的文章
PR Dandawate, A Vyas, A Ahmad, S Banerjee… - Pharmaceutical research, 2012