作者
Vincenzo Mazzaferro, Josep M Llovet, Rosalba Miceli, Sherrie Bhoori, Marcello Schiavo, Luigi Mariani, Tiziana Camerini, Sasan Roayaie, Myron E Schwartz, Gian Luca Grazi, René Adam, Peter Neuhaus, Mauro Salizzoni, Jordi Bruix, Alejandro Forner, Luciano De Carlis, Umberto Cillo, Andrew K Burroughs, Roberto Troisi, Massimo Rossi, Giorgio E Gerunda, Jan Lerut, Jacques Belghiti, Ilka Boin, Jean Gugenheim, Fedja Rochling, Bart Van Hoek, Pietro Majno
发表日期
2009/1/1
期刊
The lancet oncology
卷号
10
期号
1
页码范围
35-43
出版商
Elsevier
简介
Background
Patients undergoing liver transplantation for hepatocellular carcinoma within the Milan criteria (single tumour ≤5 cm in size or ≤3 tumours each ≤3 cm in size, and no macrovascular invasion) have an excellent outcome. However, survival for patients with cancers that exceed these criteria remains unpredictable and access to transplantation is a balance of maximising patients' chances of cure and organ availability. The aim of this study was to explore the survival of patients with tumours that exceed the Milan criteria, to assess whether the criteria could be less restrictive, enabling more patients to qualify as transplant candidates, and to derive a prognostic model based on objective tumour characteristics, to see whether the Milan criteria could be expanded.
Methods
Data on patients who underwent transplantation for hepatocellular carcinoma despite exceeding Milan criteria at different centres were …
引用总数
学术搜索中的文章
V Mazzaferro, JM Llovet, R Miceli, S Bhoori, M Schiavo… - The lancet oncology, 2009