作者
Luc GT Morris, Maximilian Linxweiler, Fengshen Kuo, Nora Katabi, Zaineb Nadeem, Martin G Dalin, Vladimir Makarov, Diego Chowell, Snjezana Dogan, Ian Ganly, A Ari Hakimi, Richard J Wong, Nadeem Riaz, Alan L Ho, Timothy A Chan, Mark Lee
发表日期
2020/1/1
期刊
Clinical Cancer Research
出版商
American Association for Cancer Research
简介
Purpose
Salivary gland carcinomas (SGC) are rare, aggressive cancers with high rates of recurrence and distant metastasis. These factors, and a lack of active systemic therapies, contribute to poor clinical outcome. Response rates with immune checkpoint blockade have been low, although clinical data remain sparse. To improve the efficacy of therapies, a more comprehensive understanding of relevant molecular alterations and immunologic processes is needed.
Experimental Design
To characterize the immune microenvironment and neoantigen landscape of SGCs, we performed RNA sequencing (RNA-seq) in 76 tumors representing the three most lethal histologies: adenoid cystic carcinoma (ACC), myoepithelial carcinoma (MECA), and salivary duct carcinoma (SDC). We analyzed transcriptomic profiles, tumor-infiltrating immune cell populations, and measures of T-cell …
学术搜索中的文章
M Linxweiler, F Kuo, N Katabi, M Lee, Z Nadeem… - Clinical Cancer Research, 2020