作者
Marc GH Besselink, Thomas J Verwer, Ernst JP Schoenmaeckers, Erik Buskens, Ben U Ridwan, Maarten R Visser, Vincent B Nieuwenhuijs, Hein G Gooszen
发表日期
2007/12/1
期刊
Archives of surgery
卷号
142
期号
12
页码范围
1194-1201
出版商
American Medical Association
简介
Objective
To determine the effect of timing of surgical intervention for necrotizing pancreatitis.
Design
Retrospective study of 53 patients and a systematic review.
Setting
A tertiary referral center.
Main Outcome Measure
Mortality.
Results
Median timing of the intervention was 28 days. Eighty-three percent of patients had infected necrosis and 55% had preoperative organ failure. The mortality rate was 36%. sixteen patients were operated on within 14 days of initial admission, 11 patients from day 15 to 29, and 26 patients on day 30 or later. This latter group received preoperative antibiotics for a longer period (P < .001), andCandidaspecies and antibiotic-resistant organisms were more often cultured from the pancreatic or peripancreatic necrosis in these patients (P = .02). The 30-day group also had the lowest mortality (8% vs 75% in the 1 to 14–days group and 45% in the 15 to 29–days group,P < .001); this difference …
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