作者
Jennifer S Rabin, Aaron P Schultz, Trey Hedden, Anand Viswanathan, Gad A Marshall, Emily Kilpatrick, Hannah Klein, Rachel F Buckley, Hyun-Sik Yang, Michael Properzi, Vaishnavi Rao, Dylan R Kirn, Kathryn V Papp, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Jasmeer P Chhatwal
发表日期
2018/9/1
期刊
JAMA neurology
卷号
75
期号
9
页码范围
1124-1131
出版商
American Medical Association
简介
Importance
Identifying asymptomatic individuals at high risk of impending cognitive decline because of Alzheimer disease is crucial for successful prevention of dementia. Vascular risk and β-amyloid (Aβ) pathology commonly co-occur in older adults and are significant causes of cognitive impairment.
Objective
To determine whether vascular risk and Aβ burden act additively or synergistically to promote cognitive decline in clinically normal older adults; and, secondarily, to evaluate the unique influence of vascular risk on prospective cognitive decline beyond that of commonly used imaging biomarkers, including Aβ burden, hippocampal volume, fludeoxyglucose F18–labeled (FDG) positron emission tomography (PET), and white matter hyperintensities, a marker of cerebrovascular disease.
Design, Setting, and Participants
In this longitudinal observational study, we examined clinically normal older adults from the …
学术搜索中的文章
JS Rabin, AP Schultz, T Hedden, A Viswanathan… - JAMA neurology, 2018