作者
Rachel F Buckley, Elizabeth C Mormino, Jennifer S Rabin, Timothy J Hohman, Susan Landau, Bernard J Hanseeuw, Heidi IL Jacobs, Kathryn V Papp, Rebecca E Amariglio, Michael J Properzi, Aaron P Schultz, Dylan Kirn, Matthew R Scott, Trey Hedden, Michelle Farrell, Julie Price, Jasmeer Chhatwal, Dorene M Rentz, Victor L Villemagne, Keith A Johnson, Reisa A Sperling
发表日期
2019/5/1
期刊
JAMA neurology
卷号
76
期号
5
页码范围
542-551
出版商
American Medical Association
简介
Importance
Mounting evidence suggests that sex differences exist in the pathologic trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal fluid tau in women compared with men as a function of apolipoprotein E (APOE) ε4 status and β-amyloid (Aβ). What remains unclear is the association of sex with regional tau deposition in clinically normal individuals.
Objective
To examine sex differences in the cross-sectional association between Aβ and regional tau deposition as measured with positron emission tomography (PET).
Design, Setting and Participants
This is a study of 2 cross-sectional, convenience-sampled cohorts of clinically normal individuals who received tau and Aβ PET scans. Data were collected between January 2016 and February 2018 from 193 clinically normal individuals from the Harvard Aging Brain Study (age range, 55-92 years; 118 women [61%]) who underwent …
学术搜索中的文章
RF Buckley, EC Mormino, JS Rabin, TJ Hohman… - JAMA neurology, 2019