作者
Rachel F Buckley, Elizabeth C Mormino, Rebecca E Amariglio, Michael J Properzi, Jennifer S Rabin, Yen Ying Lim, Kathryn V Papp, Heidi IL Jacobs, Samantha Burnham, Bernard J Hanseeuw, Vincent Doré, Annette Dobson, Colin L Masters, Michael Waller, Christopher C Rowe, Paul Maruff, Michael C Donohue, Dorene M Rentz, Dylan Kirn, Trey Hedden, Jasmeer Chhatwal, Aaron P Schultz, Keith A Johnson, Victor L Villemagne, Reisa A Sperling, Alzheimer's Disease Neuroimaging Initiative
发表日期
2018/9/1
期刊
Alzheimer's & Dementia
卷号
14
期号
9
页码范围
1193-1203
出版商
No longer published by Elsevier
简介
Introduction
Our objective was to investigate the effect of sex on cognitive decline within the context of amyloid β (Aβ) burden and apolipoprotein E genotype.
Methods
We analyzed sex-specific effects on Aβ-positron emission tomography, apolipoprotein, and rates of change on the Preclinical Alzheimer Cognitive Composite-5 across three cohorts, such as the Alzheimer's Disease Neuroimaging Initiative, Australian Imaging, Biomarker and Lifestyle, and Harvard Aging Brain Study (n = 755; clinical dementia rating = 0; age (standard deviation) = 73.6 (6.5); female = 55%). Mixed-effects models of cognitive change by sex, Aβ-positron emission tomography, and apolipoprotein ε4 were examined with quadratic time effects over a median of 4 years of follow-up.
Results
Apolipoprotein ε4 prevalence and Aβ burden did not differ by sex. Sex did not directly influence cognitive decline. Females with higher Aβ exhibited faster …
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RF Buckley, EC Mormino, RE Amariglio, MJ Properzi… - Alzheimer's & Dementia, 2018