作者
M Elizabeth H Hammond, Daniel F Hayes, Mitch Dowsett, D Craig Allred, Karen L Hagerty, Sunil Badve, Patrick L Fitzgibbons, Glenn Francis, Neil S Goldstein, Malcolm Hayes, David G Hicks, Susan Lester, Richard Love, Pamela B Mangu, Lisa McShane, Keith Miller, C Kent Osborne, Soonmyung Paik, Jane Perlmutter, Anthony Rhodes, Hironobu Sasano, Jared N Schwartz, Fred CG Sweep, Sheila Taube, Emina Emilia Torlakovic, Paul Valenstein, Giuseppe Viale, Daniel Visscher, Thomas Wheeler, R Bruce Williams, James L Wittliff, Antonio C Wolff
发表日期
2010/6/1
来源
Journal of Clinical Oncology
卷号
28
期号
16
页码范围
2784-2795
出版商
American Society of Clinical Oncology
简介
Purpose
To develop a guideline to improve the accuracy of immunohistochemical (IHC) estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the utility of these receptors as predictive markers.
Methods
The American Society of Clinical Oncology and the College of American Pathologists convened an international Expert Panel that conducted a systematic review and evaluation of the literature in partnership with Cancer Care Ontario and developed recommendations for optimal IHC ER/PgR testing performance.
Results
Up to 20% of current IHC determinations of ER and PgR testing worldwide may be inaccurate (false negative or false positive). Most of the issues with testing have occurred because of variation in preanalytic variables, thresholds for positivity, and interpretation criteria.
Recommendations
The Panel recommends that ER and PgR status be determined on all …
引用总数
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MEH Hammond, DF Hayes, M Dowsett, DC Allred… - Journal of Clinical Oncology, 2010