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Background: Over 2 billion world people suffer from iron deficiency. Teenager girls are one of vulnerable groups in this area. Health education with various methods is a suitable tool for motivating and modifying incorrect function. The purpose of this research was determining the effect of health education program base on PRECEDE Model for controlling iron-deficiency anemia. Materials and Methods: This quasi-experimental and two-phase study was done on 72 students placed into case and control groups in 2007-8. Intervention was done in three sections with 45 minutes and 3 months after educational intervention was followed. Questionnaire base on PRECEDE Model parts and blood lab exams (Hb, Hct, Feritin) were data gathering tool. Data were analyzed by pair T-test, independent T-test, Mann-Whitney and Chi-square tests. Results: The mean score of knowledge (p< 0.001) and attitude (p< 0.001)(Predisposing factors), Using educational resources, taking place educational class and participating in educational programs (Enabling factors), encourage family and teachers (Reinforcing factors) and iron deficiency anemia preventive behaviors had a significant increase in the case group after the educational intervention. Conclusion: Above results indicate positive effect of educational intervention program base on PRECEDE Model and main components (Predisposing, Enabling, Reinforcing factors) in improving of iron deficiency anemia preventive behaviors in the study population.