作者
Ze-Yong Li, Yun Liu, Xiao-Qiang Wang, Li-Han Liu, Jing-Jing Hu, Guo-Feng Luo, Wei-Hai Chen, Lei Rong, Xian-Zheng Zhang
发表日期
2013/8/28
期刊
ACS applied materials & interfaces
卷号
5
期号
16
页码范围
7995-8001
出版商
American Chemical Society
简介
Mesoporous silica nanoparticles (MSNs) have proved to be an effective carrier for controlled drug release and can be functionalized easily for use as stimuli-responsive vehicles. Here, a novel intelligent drug-delivery system (DDS), camptothecin (CPT)-loaded and doxorubicin (DOX)-conjugated MSN (CPT@MSN-hyd-DOX), is reported via a facile one-pot preparation for use in synergistic chemotherapy of glioblastoma. DOX was conjugated to MSNs via acid-labile hydrazone bonds, and CPT was loaded in the pores of the MSNs. At pH 6.5 (analogous to the pH in tumor tissues), a fast DOX release was observed that was attributed to the hydrolysis of the hydrazone bonds. In addition, a further burst release of DOX was found at pH 5.0 (analogous to the pH in lyso/endosomes of tumor cells), leading to a strong synergistic effect. In all, CPT and DOX could be delivered simultaneously into tumor cells, and this intelligent …
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