作者
Jin Li, Shaoqiang Lin, Paul M Vanhoutte, Connie W Woo, Aimin Xu
发表日期
2016/6/14
期刊
Circulation
卷号
133
期号
24
页码范围
2434-2446
出版商
Lippincott Williams & Wilkins
简介
Background
Altered composition of the gut microbiota is involved in both the onset and progression of obesity and diabetes mellitus. However, the link between gut microbiota and obesity-related cardiovascular complications has not been explored. The present study was designed to investigate the role of Akkermansia muciniphila, a mucin-degrading bacterium with beneficial effects on metabolism, in the pathogenesis of atherosclerosis in apolipoprotein E–deficient (Apoe−/−) mice.
Methods and Results
Apoe−/− mice on normal chow diet or a Western diet were treated with A muciniphila by daily oral gavage for 8 weeks, followed by histological evaluations of atherosclerotic lesion in aorta. Real-time polymerase chain reaction analysis demonstrated that the fecal abundance of A muciniphila was significantly reduced by Western diet. Replenishment with A muciniphila reversed Western diet–induced exacerbation of …
学术搜索中的文章
J Li, S Lin, PM Vanhoutte, CW Woo, A Xu - Circulation, 2016
S Lin, PM Vanhoutte, CW Woo, A Xu - Circulation, 2016