作者
Aimin Xu, YU Wang, Jian Yu Xu, David Stejskal, Sidney Tam, Jialiang Zhang, Nelson MS Wat, Wai Keung Wong, Karen SL Lam
发表日期
2006/3/1
期刊
Clinical chemistry
卷号
52
期号
3
页码范围
405-413
出版商
Oxford University Press
简介
Background: Adipocyte fatty acid–binding protein (A-FABP) is traditionally thought to be a cytosolic fatty acid chaperone expressed in adipocytes. Mice with targeted disruption of the A-FABP gene exhibit a striking phenotype with strong protection from insulin resistance, hyperglycemia, and atherosclerosis. The clinical relevance of these findings remains to be confirmed.
Methods: We used tandem mass spectrometry–based proteomic analysis to identify proteins secreted from adipocytes and present in human serum. We measured serum A-FABP concentrations in 229 persons (121 men and 108 women; age range, 33–72 years), including 100 lean [body mass index (BMI) <25 kg/m2] and 129 overweight/obese individuals (BMI >25 kg/m2) selected from a previous cross-sectional study.
Results: A-FABP was released from adipocytes and was abundantly present in human serum …
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A Xu, YU Wang, JY Xu, D Stejskal, S Tam, J Zhang… - Clinical chemistry, 2006