作者
Khaled Mohey El-Din Monib, Hanan Hassan Sabry, Mohamed Saber Hussein, Asmaa Adel El-Fallah, Rehab Mohammed Salem
发表日期
2022/4/3
期刊
Journal of Dermatological Treatment
卷号
33
期号
3
页码范围
1351-1355
出版商
Taylor & Francis
简介
Background
Factors contributing to the pathogenesis of vitiligo and factors affecting its response to treatment are still a major area of debate.
Aim of the work
The study aimed to assess the serum levels of tyrosinase and Micro-RNAs (miRNAs) gene polymorphism in a sample of Egyptian vitiligo patients, and to determine factors affecting the response of vitiligo to treatment.
Subjects and methods
This prospective case-control interventional study included 212 non-segmental vitiligo patients and 96 control subjects. Before treatment, vitiligo was evaluated using Vitiligo Area Severity Index. Detection of miRNA 196a-2 polymorphism was done using PCR-REELP and serum tyrosinase was measured using ELISA. After treatment, patients were reevaluated clinically and serum tyrosinase levels were re-measured.
Results
The tyrosinase levels were significantly elevated in patients. The TT genotype was the most prevalent …
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KMED Monib, HH Sabry, MS Hussein, AA El-Fallah… - Journal of Dermatological Treatment, 2022