作者
Kimberly G Blumenthal, Na Lu, Yuqing Zhang, Yu Li, Rochelle P Walensky, Hyon K Choi
发表日期
2018/6/27
期刊
bmj
卷号
361
出版商
British Medical Journal Publishing Group
简介
Objective
To evaluate the relation between penicillin allergy and development of meticillin resistant Staphylococcus aureus (MRSA) and C difficile.
Design
Population based matched cohort study.
Setting
United Kingdom general practice (1995-2015).
Participants
301 399 adults without previous MRSA or C difficile enrolled in the Health Improvement Network database: 64 141 had a penicillin allergy and 237 258 comparators matched on age, sex, and study entry time.
Main outcome measures
The primary outcome was risk of incident MRSA and C difficile. Secondary outcomes were use of β lactam antibiotics and β lactam alternative antibiotics.
Results
Among 64 141 adults with penicillin allergy and 237 258 matched comparators, 1365 developed MRSA (442 participants with penicillin allergy and 923 comparators) and 1688 developed C difficile (442 participants with penicillin allergy and 1246 comparators …
学术搜索中的文章
KG Blumenthal, N Lu, Y Zhang, Y Li, RP Walensky… - bmj, 2018