作者
Xiaoxin Chen, Su Wang, Nan Wu, Sandeep Sood, Peng Wang, Zhe Jin, David G Beer, Thomas J Giordano, Yong Lin, Wei-chung J Shih, Ronald A Lubet, Chung S Yang
发表日期
2004/10/1
期刊
Clinical cancer research
卷号
10
期号
19
页码范围
6703-6709
出版商
American Association for Cancer Research
简介
Purpose: Aberrant arachidonic acid (AA) metabolism, especially through the cyclooxygenase (Cox) and 5-lipoxygenase (5-Lox) pathways, has been suggested to play an important role in the development of esophageal adenocarcinoma (EAC). The purpose of this study was to investigate the expression of 5-Lox in EAC of a rat model and in human samples as well as the chemopreventive effects of zileuton (a specific 5-Lox inhibitor) and celecoxib (a specific Cox2 inhibitor) in the rat EAC model.
Experimental Design: 5-Lox expression in EAC of a rat esophagogastroduodenal anastomosis model and of humans was examined with immunohistochemistry. A chemoprevention study was designed to test whether zileuton and celecoxib could suppress aberrant AA metabolism and esophageal adenocarcinogenesis.
Results: With immunohistochemistry, we found that 5-Lox was …
引用总数
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X Chen, S Wang, N Wu, S Sood, P Wang, Z Jin… - Clinical cancer research, 2004