作者
Gemma Chiva-Blanch, Mireia Urpi-Sarda, Emilio Ros, Sara Arranz, Palmira Valderas-Martínez, Rosa Casas, Emilio Sacanella, Rafael Llorach, Rosa M Lamuela-Raventos, Cristina Andres-Lacueva, Ramon Estruch
发表日期
2012/9/28
期刊
Circulation research
卷号
111
期号
8
页码范围
1065-1068
出版商
Lippincott Williams & Wilkins
简介
Rationale:
Experimental studies have shown a potential blood pressure (BP) lowering effect of red wine polyphenols, whereas the effects of ethanol and polyphenols on BP in humans are not yet clear.
Objective:
The aim of the present work was to evaluate the effects of red wine fractions (alcoholic and nonalcoholic) on BP and plasma nitric oxide (NO) in subjects at high cardiovascular risk.
Methods and Results:
Sixty-seven men at high cardiovascular risk were studied. After a 2-week run-in period, subjects were randomized into 3 treatment periods in a crossover clinical trial, with a common background diet plus red wine (30g alcohol/day), the equivalent amount of dealcoholized red wine, or gin (30g alcohol/day), lasting 4 weeks each intervention. At baseline and after each intervention, anthropometrical parameters, BP and plasma NO were measured. Systolic and diastolic BP decreased significantly after the …
学术搜索中的文章
G Chiva-Blanch, M Urpi-Sarda, E Ros, S Arranz… - Circulation research, 2012