作者
Aleksandra Gąsecka, Josip A Borovac, Rui Azevedo Guerreiro, Michela Giustozzi, William Parker, Daniel Caldeira, Gemma Chiva-Blanch
发表日期
2021/4
来源
Cardiovascular drugs and therapy
卷号
35
页码范围
215-229
出版商
Springer US
简介
Introduction
Emerging evidence points to an association between severe clinical presentation of COVID-19 and increased risk of thromboembolism. One-third of patients hospitalized due to severe COVID-19 develops macrovascular thrombotic complications, including venous thromboembolism, myocardial injury/infarction and stroke. Concurrently, the autopsy series indicate multiorgan damage pattern consistent with microvascular injury.
Prophylaxis, diagnosis and treatment
COVID-19 associated coagulopathy has distinct features, including markedly elevated D-dimers concentration with nearly normal activated partial thromboplastin time, prothrombin time and platelet count. The diagnosis may be challenging due to overlapping features between pulmonary embolism and severe COVID-19 disease, such as dyspnoea, high concentration of D-dimers …
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A Gąsecka, JA Borovac, RA Guerreiro, M Giustozzi… - Cardiovascular drugs and therapy, 2021