作者
Kaixin Zhou, Louise Donnelly, Jian Yang, Miaoxin Li, Harshal Deshmukh, Natalie Van Zuydam, Emma Ahlqvist, Chris C Spencer, Leif Groop, Andrew D Morris, Helen M Colhoun, Pak C Sham, Mark I McCarthy, Colin NA Palmer, Ewan R Pearson
发表日期
2014/6/1
期刊
The lancet Diabetes & endocrinology
卷号
2
期号
6
页码范围
481-487
出版商
Elsevier
简介
Background
Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.
Methods
In this GCTA study, we obtained data about HbA1c concentrations before and during metformin treatment from patients in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) study, which includes a cohort of patients with type 2 diabetes and is linked to comprehensive clinical databases and genome-wide association study data. We applied the GCTA method to estimate heritability for four definitions of glycaemic response to metformin: absolute reduction in HbA1c; proportional …
学术搜索中的文章
K Zhou, L Donnelly, J Yang, M Li, H Deshmukh… - The lancet Diabetes & endocrinology, 2014