作者
Tania R. Dias, Ana D. Martins, Vania P. Reis, Sílvia Socorro, Branca M. Silva, Marco G. Alves, Pedro F. Oliveira
发表日期
2013/12/1
期刊
Current Chemical Biology
卷号
7
期号
3
页码范围
282-293
出版商
Bentham Science Publishers
简介
Sertoli cells (SCs) are essential for the testis functional development and hence for the expression of male phenotype. They provide a unique and protected environment in testis, within the seminiferous tubules, necessary for the successful progression of germ cells into fully competent spermatozoa. SC has the ability to metabolize various substrates, but preferentially uses glucose that is converted to pyruvate and lactate. This is a crucial event since lactate is essential for germ cells survival and development due to its anti-apoptotic effect and its role as energy source. Glucose metabolism in SCs is under the complex control of several hormones, predominantly sex steroid hormones, thyroid hormones (THs): follicle- stimulating hormone (FSH) and insulin. This process may occur without the requirement of protein synthesis, suggesting a modulation of enzyme activity and/or regulation of glucose transport. The …
引用总数
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T R. Dias, A D. Martins, V P. Reis, S Socorro, B M. Silva… - Current Chemical Biology, 2013