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Recent reports suggest a possibly protective effect for statins in patients with Alzheimer disease. This association could be due to indication bias, ie, people who elect to take lipid-lowering agents (LLAs) may be healthier than those who do not, so that it may be these other health factors that explain their lower risk of dementia.

To examine the association between the use of LLAs and dementia, adjusting for other markers of health, and to investigate factors associated with LLA use.

A cohort study of LLA use and a case-control study of dementia in relation to LLA use, in a secondary analysis of the Canadian Study of Health and Aging.

A nationally representative population-based survey of Canadians 65 years and older.

To examine features associated with statin use, we evaluated data on 2305 people for whom health information, drug use, and cognitive status were …