作者
Marta Michalska-Kasiczak, Amirhossein Sahebkar, Dimitri P Mikhailidis, Jacek Rysz, Paul Muntner, Peter P Toth, Steven R Jones, Manfredi Rizzo, G Kees Hovingh, Michel Farnier, Patrick M Moriarty, Vera A Bittner, Gregory YH Lip, Maciej Banach, Lipid and Blood Pressure Meta-analysis Collaboration
发表日期
2015/1/15
来源
International journal of cardiology
卷号
178
页码范围
111-116
出版商
Elsevier
简介
Introduction
Vitamin D (vit D) deficiency may be associated with an increased risk of statin-related symptomatic myalgia in statin-treated patients. The aim of this meta-analysis was to substantiate the role of serum vitamin D levels in statin-associated myalgia.
Methods
The search included PUBMED, Cochrane Library, Scopus, and EMBASE from January 1, 1987 to April 1, 2014 to identify studies that investigated the impact of vit D levels in statin-treated subjects with and without myalgia. Two independent reviewers extracted data on study characteristics, methods and outcomes. Quantitative data synthesis was performed using a fixed-effect model.
Results
The electronic search yielded 437 articles; of those 20 were scrutinized as full texts and 13 studies were considered unsuitable. The final analysis included 7 studies with 2420 statin-treated patients divided into subgroups of patients with (n = 666 [27.5%]) or without (n …
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M Michalska-Kasiczak, A Sahebkar, DP Mikhailidis… - International journal of cardiology, 2015