作者
Michael Helton, Mary-Ann Mycek, Karthik Vishwanath
发表日期
2022/3/1
期刊
Biomedical Optics Express
卷号
13
期号
3
页码范围
1595-1608
出版商
Optica Publishing Group
简介
Measurements of time-resolved reflectance from a homogenous turbid medium can be employed to retrieve the absolute values of its optical transport coefficients. However, the uncertainty in the temporal shift of the experimentally determined instrument response function (IRF) with respect to the real system response can lead to errors in optical property reconstructions. Instrument noise and measurement of the IRF in a reflectance geometry can exacerbate these errors. Here, we examine three reconstruction approaches that avoid requiring direct measurements of photon launch times. They work by (a) fitting relative shapes of the reflectance profile with a pre-determined constraint on the scattering coefficient, (b) calibrating launch-time differences via a reference sample, and (c) freely fitting for the launch-time difference within the inverse problem. Analysis methods that can place a tight bound on the scattering …
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M Helton, MA Mycek, K Vishwanath - Biomedical Optics Express, 2022