作者
Jean-Charles Lambert, Benjamin Grenier-Boley, Denise Harold, Diana Zelenika, Vincent Chouraki, Yoichiro Kamatani, Kristel Sleegers, MA Ikram, Mikko Hiltunen, Christiane Reitz, Ignacio Mateo, Thomas Feulner, Maria Bullido, Daniela Galimberti, Letizia Concari, Victoria Alvarez, Rebecca Sims, Amy Gerrish, Jade Chapman, C Deniz-Naranjo, Vincenzo Solfrizzi, Sandro Sorbi, Beatrice Arosio, Gianfranco Spalletta, Gabriele Siciliano, Jacques Epelbaum, Didier Hannequin, Jean-François Dartigues, Christophe Tzourio, Claudine Berr, Elisabeth MC Schrijvers, R Rogers, Giuseppe Tosto, Florence Pasquier, Karolien Bettens, Caroline Van Cauwenberghe, Laura Fratiglioni, C Graff, Marc Délépine, Raffaele Ferri, Chandra A Reynolds, Lars Lannfelt, Martin Ingelsson, Jonathan A Prince, Caterina Chillotti, Alberto Pilotto, Davide Seripa, Anne Boland, Michelangelo Mancuso, Paola Bossù, Giorgio Annoni, Benedetta Nacmias, Paolo Bosco, Francesco Panza, Florentino Sanchez-Garcia, Maria Del Zompo, Eliecer Coto, Michael Owen, Michael O'Donovan, Fernando Valdivieso, P Caffara, Elio Scarpini, Onofre Combarros, Luc Buée, Dominique Campion, H Soininen, Monique Breteler, Matthias Riemenschneider, Christine Van Broeckhoven, Annick Alperovitch, Marc Lathrop, David-Alexandre Trégouët, Julie Williams, Philippe Amouyel
发表日期
2013/4
期刊
Molecular psychiatry
卷号
18
期号
4
页码范围
461-470
出版商
Nature Publishing Group
简介
Recently, several genome-wide association studies (GWASs) have led to the discovery of nine new loci of genetic susceptibility in Alzheimer's disease (AD). However, the landscape of the AD genetic susceptibility is far away to be complete and in addition to single-SNP (single-nucleotide polymorphism) analyses as performed in conventional GWAS, complementary strategies need to be applied to overcome limitations inherent to this type of approaches. We performed a genome-wide haplotype association (GWHA) study in the EADI1 study (n= 2025 AD cases and 5328 controls) by applying a sliding-windows approach. After exclusion of loci already known to be involved in AD (APOE, BIN1 and CR1), 91 regions with suggestive haplotype effects were identified. In a second step, we attempted to replicate the best suggestive haplotype associations in the GERAD1 consortium (2820 AD cases and 6356 controls) and …
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JC Lambert, B Grenier-Boley, D Harold, D Zelenika… - Molecular psychiatry, 2013