作者
Jie Huang, Jennifer E Huffman, Yunfeng Huang, Ítalo Do Valle, Themistocles L Assimes, Sridharan Raghavan, Benjamin F Voight, Chang Liu, Albert-László Barabási, Rose DL Huang, Qin Hui, Xuan-Mai T Nguyen, Yuk-Lam Ho, Luc Djousse, Julie A Lynch, Marijana Vujkovic, Catherine Tcheandjieu, Hua Tang, Scott M Damrauer, Peter D Reaven, Donald Miller, Lawrence S Phillips, Maggie CY Ng, Mariaelisa Graff, Christopher A Haiman, Ruth JF Loos, Kari E North, Loic Yengo, George Davey Smith, Danish Saleheen, J Michael Gaziano, Daniel J Rader, Philip S Tsao, Kelly Cho, Kyong-Mi Chang, Peter WF Wilson, VA Million Veteran Program, Yan V Sun, Christopher J O’Donnell
发表日期
2022/12/29
期刊
Nature Communications
卷号
13
期号
1
页码范围
7973
出版商
Nature Publishing Group UK
简介
Elevated body mass index (BMI) is heritable and associated with many health conditions that impact morbidity and mortality. The study of the genetic association of BMI across a broad range of common disease conditions offers the opportunity to extend current knowledge regarding the breadth and depth of adiposity-related diseases. We identify 906 (364 novel) and 41 (6 novel) genome-wide significant loci for BMI among participants of European (N~1.1 million) and African (N~100,000) ancestry, respectively. Using a BMI genetic risk score including 2446 variants, 316 diagnoses are associated in the Million Veteran Program, with 96.5% showing increased risk. A co-morbidity network analysis reveals seven disease communities containing multiple interconnected diseases associated with BMI as well as extensive connections across communities. Mendelian randomization analysis confirms numerous phenotypes …
学术搜索中的文章
J Huang, JE Huffman, Y Huang, Í Do Valle, TL Assimes… - Nature Communications, 2022