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Materials and Methods: This study evaluated 160 attachments including 80 Locator and 80 Dalbo-Plus attachment systems. The attachments were mounted in acrylic resin blocks and were subjected to a universal testing machine to measure their baseline retention. Each attachment system was randomly divided into four groups for immersion in cleansing solutions namely water, 5% sodium hypochlorite diluted 1: 10, Dentipur denture cleanser, and Corega denture cleanser for a period of time corresponding to 6 months of clinical service. The attachments’ retention was measured again after the immersion period. Data were analyzed using ANOVA and Tukey’s test.

Results: The retention of Dalbo-Plus attachments in water and Dentipur was significantly higher than that in other solutions (P< 0.05). The Locator attachments had the highest retention in Dentipur followed by water, Corega, and sodium hypochlorite. The retention of Locator attachments was significantly higher than that of Dalbo-Plus in all solutions (P< 0.05). Immersion of attachments in Dentipur in-creased their retention. Locator attachment showed higher retention than the Dalbo-Plus irrespective of the type of cleansing solution.

Conclusion: Dentipur can serve as a suitable denture cleanser since it increased the retention of attachments. Corega decreased the retention of attachments and should be used with care.