作者
Michael J Allen, Amy Zhang, Prashant Bavi, Jaeseung C Kim, Gun Ho Jang, Deirdre Kelly, Sheron Perera, Rob E Denroche, Faiyaz Notta, Julie M Wilson, Anna Dodd, Stephanie Ramotar, Shawn Hutchinson, Sandra E Fischer, Robert C Grant, Steven Gallinger, Jennifer J Knox, Grainne M O'Kane
发表日期
2023/3/1
来源
Journal of Clinical Pathology
卷号
76
期号
3
页码范围
158-165
出版商
BMJ Publishing Group
简介
Aims
The majority of pancreatic ductal adenocarcinomas (PDACs) harbour oncogenic mutations in KRAS with variants in TP53, CDKN2A and SMAD4 also prevalent. The presence of oncogenic fusions including NTRK fusions are rare but important to identify. Here we ascertain the prevalence of NTRK fusions and document their genomic characteristics in a large series of PDAC.
Methods
Whole genome sequencing and RNAseq were performed on a series of patients with resected or locally advanced/metastatic PDAC collected between 2008 and 2020 at a single institution. A subset of specimens underwent immunohistochemistry (IHC) analysis. Clinical and molecular characterisation and IHC sensitivity and specificity were evaluated.
Results
400 patients were included (resected n=167; locally advanced/metastatic n=233). Three patients were identified as harbouring an NTRK fusion, two EML4-NTRK3 (KRAS-WT …
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MJ Allen, A Zhang, P Bavi, JC Kim, GH Jang, D Kelly… - Journal of Clinical Pathology, 2023