作者
J Linden
发表日期
2001/4
来源
Annual review of pharmacology and toxicology
卷号
41
期号
1
页码范围
775-787
出版商
Annual Reviews
简介
Adenosine accumulation during ischemia and inflammation protects tissues from injury. In ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in inflamed tissues adenosine is formed from adenine nucleotides that are released from many cells including platelets, mast cells, nerves, and endothelium. Nucleotides are rapidly converted to adenosine by a family of ecto-nucleotidases including CD39 and CD73. Activation of A1 and possibly A3 adenosine receptors (ARs) protects heart and other tissues by preconditioning through a pathway including protein kinase C and mitochondrial KATP channels. Activation of A2A receptors limits reperfusion injury by inhibiting inflammatory processes in neutrophils, platelets, macrophages and T cells. Adenosine produces proinflammatory responses mediated by receptors that vary among species; A3 and A2B receptors mediate degranulation of …
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J Linden - Annual review of pharmacology and toxicology, 2001