作者
Hanieh Yaghootkar, Claudia Lamina, Robert A Scott, Zari Dastani, Marie-France Hivert, Liling L Warren, Alena Stancáková, Sarah G Buxbaum, Leo-Pekka Lyytikäinen, Peter Henneman, Ying Wu, Chloe YY Cheung, James S Pankow, Anne U Jackson, Stefan Gustafsson, Jing Hua Zhao, Christie M Ballantyne, Weijia Xie, Richard N Bergman, Michael Boehnke, Fatiha El Bouazzaoui, Francis S Collins, Sandra H Dunn, Josee Dupuis, Nita G Forouhi, Christopher Gillson, Andrew T Hattersley, Jaeyoung Hong, Mika Kähönen, Johanna Kuusisto, Lyudmyla Kedenko, Florian Kronenberg, Alessandro Doria, Themistocles L Assimes, Ele Ferrannini, Torben Hansen, Ke Hao, Hans Häring, Joshua W Knowles, Cecilia M Lindgren, John J Nolan, Jussi Paananen, Oluf Pedersen, Thomas Quertermous, Ulf Smith, GENESIS Consortium, RISC Consortium, Terho Lehtimäki, Ching-Ti Liu, Ruth JF Loos, Mark I McCarthy, Andrew D Morris, Ramachandran S Vasan, Tim D Spector, Tanya M Teslovich, Jaakko Tuomilehto, Ko Willems van Dijk, Jorma S Viikari, Na Zhu, Claudia Langenberg, Erik Ingelsson, Robert K Semple, Alan R Sinaiko, Colin NA Palmer, Mark Walker, Karen SL Lam, Bernhard Paulweber, Karen L Mohlke, Cornelia van Duijn, Olli T Raitakari, Aurelian Bidulescu, Nick J Wareham, Markku Laakso, Dawn M Waterworth, Debbie A Lawlor, James B Meigs, J Brent Richards, Timothy M Frayling
发表日期
2013/10/1
来源
Diabetes
卷号
62
期号
10
页码范围
3589-3598
出版商
American Diabetes Association
简介
Adiponectin is strongly inversely associated with insulin resistance and type 2 diabetes, but its causal role remains controversial. We used a Mendelian randomization approach to test the hypothesis that adiponectin causally influences insulin resistance and type 2 diabetes. We used genetic variants at the ADIPOQ gene as instruments to calculate a regression slope between adiponectin levels and metabolic traits (up to 31,000 individuals) and a combination of instrumental variables and summary statistics–based genetic risk scores to test the associations with gold-standard measures of insulin sensitivity (2,969 individuals) and type 2 diabetes (15,960 case subjects and 64,731 control subjects). In conventional regression analyses, a 1-SD decrease in adiponectin levels was correlated with a 0.31-SD (95% CI 0.26–0.35) increase in fasting insulin, a 0.34-SD (0.30–0.38) decrease in insulin sensitivity, and a type 2 …
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H Yaghootkar, C Lamina, RA Scott, Z Dastani… - Diabetes, 2013